Publications

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Publications since 2014

  • Carlton, L., Morsy, H., Gilley, J., Houlden, H., Reilly, M.M., Coleman, M.P., Wilson, E.R. (2026) Human promoter analysis of the Programmed Axon Death genes NMNAT2 and SARM1. preprint. doi: https://doi.org/10.64898/2026.03.23.712947 

  • White, M.A., Crowley, L., Massenzio, F., Li, X., Niblock, M., Coleman, M.P., Sreedharan, J. (2026) Inhibiting glycogen synthase kinase 3 suppresses TDP-43-mediated neurotoxicity in a caspase-dependent manner. Molecular Neurobiology.epub ahead of print. DOI: 10.21203/rs.3.rs-6527592/v1

  • Loreto, A., Cramb, K.M.L., McDermott, L.A., Antoniou, C., Cirilli I., Caiazza, M.C. , Merlini, E., Arthur-Farraj, P., Mock, E.D., Zhao, H.T., Bennett, D.L., Orsomando, G., Coleman,  M.P., Wade-Martins, R. (2025) SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides. Neurobiology of Disease. 213: 106986. doi: 10.1016/j.nbd.2025.106986
  • Antoniou, C., Loreto, A., Gilley, J., Merlini, E., Orsomando, G., Coleman, M.P. (2024) Chronically low NMNAT2 expression causes sub-lethal SARM1 activation and altered response to nicotinamide riboside in axon. Molecular Neurobiology. 62: 3903-3917. doi: 10.1007/s12035-024-04480-2
  • Groh, J., Abdelwahab, T., Kattimani, Y., et al. (2023) Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects. Nat Commun14: 6911. https://doi.org/10.1038/s41467-023-42570-2
  • Mutschler, C., Fazal, S.V., Schumacher, N., Loreto, A., Coleman, M.P., Arthur-Farraj, P. (2023) Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell-neuron cocultures. J Cell Sci. 15:136 :jcs261557. doi: 10.1242/jcs.261557
  • ​​​​​​​Fazal, S.V., Mutschler, C., Chen, C.Z., Turmaine, M., Chen, C.Y., Hsueh, Y.P., Ibañez-Grau, A., Loreto, A., Casillas-Bajo, A., Cabedo, H., Franklin, R.J.M., Barker, R.A., Monk, K.R., Steventon, B.J., Coleman, M.P., Gomez-Sanchez, J.A., Arthur-Farraj, P. (2023) SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice’ Front Cell Neurosci.17:1158388. doi: 10.3389/fncel.2023.1158388
  • ​​​​​​​Loreto A, Antoniou C, Merlini E, Gilley J, Coleman MP. (2023) NMN: The NAD precursor at the intersection between axon degeneration and anti-ageing therapies. Neurosci Res. Dec;197:18-24. doi: 10.1016/j.neures.2023.01.004. Epub 2023 Jan 16. PMID: 36657725​​​​​​​
  • ​​​​​​​Niou, Z., Yang, S., Sri, A., Rodriguez, H., Gilley, J., Coleman, M.P., Lu, H. (2022) NMNAT2 in cortical glutamatergic neurons exerts both cell and non-cell autonomous influences to shape cortical development and to maintain neuronal health. doi: https://doi.org/10.1101/2022.02.05.479195​​​​​​​
  • ​​​​​​​Adalbert R, Cahalan S, Hopkins EL, Almuhanna A, Loreto A, Pór E, Körmöczy L, Perkins J, Coleman MP, Piercy RJ. (2022) Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport. J Anat. Nov;241(5):1211-1218. doi: 10.1111/joa.13719. Epub 2022 Jun 21. PMID: 35728923; PMCID: PMC9558156
  • ​​​​​​​Rosell, A.L., Paglione, M., Gilley, J., Kocia, M., Gasparrini, M., Cialabrinim L., Raffaelli, B., Angeletti, C., Orsomando, G., Coleman, M.P., Loreto, A., Neukomm, L.J. (2022) The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila. eLife. doi: 10.7554/eLife.80245
  • ​​​​​Coleman, M.P (2022) ‘Axon biology in ALS: mechanisms of axon degeneration and prospects for therapy’, Neurotherapeutics. doi: 10.1007/s13311-022-01297-6.
  • Ademi, M., Yang, X., Coleman, M.P., Gilley, J. (2022): Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival.’ Scientific Reports 12(1):13846. doi: 10.1038/s41598-022-18052-8
  • Crawford, C., Antoniou, C., Komarek, L., Schultz, V., Donald, C.L., Montague, P., Barnett, S.C., Linnington, C., Willison, H.J., Kohl, A., Coleman, M.P.*, Edgar, J.M.* (2022) ‘SARM1 depletion slows axon degeneration in a CNS model of neurotropic viral infection.’ Front Mol Neurosci 15: 860410
  • Angeletti, C., Amici, A., Gilley, J. ..., Merlini, E., Coleman, M.P.*, Orsomando, G.* (2022) SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated by multiple physiologically relevant NAD metabolites. iScience 25: 103812. doi: 10.1016/j.isci.2022.103812
  • Merlini, E., Coleman, M.P., Loreto, A. (2022) Mitochondrial dysfunction as a trigger for programmed axon death. Trends Neurosci. 45: 53-63
  • Miller, L.V.C., Mukadam, A.S., Durrant, C.S., Vaysburd, M. J., Katsinelos, T., Tuck, B.J., Sanford, S., Sheppard, O., Knox, C., Cheng, S., James, L.C., Coleman, M.P., McEwan, W.A. (2021) Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue. Acta Neuropathol Commun. Mar 12;9:41. doi: 10.1186/s40478-021-01141-6
  • ​​​​​​​Lin, Z., Kim, E., Ahmed, M., Han, G., Simmons, C., Redhead, Y., Bartlett, J., Pena Altamira, L.E., Callaghan, I., White, M.A., Singh, N., Sawiak, S., Spires-Jones, T., Vernon, A.C., Coleman, M.P., Green, J., Henstridge, C., Davies, J.S., Cash, D., Sreedharan, J. (2021) ‘MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in amyotrophic lateral sclerosis-frontotemporal dementia.’ Brain Commun. 2021 3 (2):114. doi: 10.1093/braincomms/fcab114. PMID: 34136812; PMCID: PMC8204366.
  • Loreto, A., Angeletti, C., Gu, W., Osborne, A., Nieuwenhuis, B., Gilley, J., Arthur-Farraj, P., Merlini, E., Amici, A., Luo, Z., Hartley-Tassell, L., Ve, T., Desrochers, L.M., Wang, Q., Kobe, B., Orsomando, G., Coleman, M.P. (2021) “Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1”. eLife 10: e72823
  • Gilley, J., Jackson, O., Pipis, M., Estiar, M.A., Al-Chalabi, A., Danzi, M.C., van Eijk, K.R.,  Goutman, S.A., Harms, M.B., Houlden, H., Iacoangeli, A., Kaye, J., Lima, L. Queen Square Genomics, Ravits, J., Rouleau, G.A., Schüle, R., Xu, J., Züchner, S., Cooper-Knock, J., Gan-Or, Z., Reilly, M.M. and Coleman, M.P. (2021) “Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders”. eLife 10: e70905. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735862
  • Arthur-Farraj, P., and Coleman, M.P. (2021) ‘Lessons from injury: how nerve injury studies reveal basic biological mechanisms and therapeutic opportunities for peripheral nerve diseases. Neurotherapeutics 18: 2200-2221.
  • Gilley, J., Jackson, O., Pipis, M., Estiar, M.A., Al-Chalabi, A., Danzi, M.C., van Eijk, K.R.,  Goutman, S.A., Harms, M.B., Houlden, H., Iacoangeli, A., Kaye, J., Lima, L. Queen Square Genomics, Ravits, J., Rouleau, G.A., Schüle, R., Xu, J., Züchner, S., Cooper-Knock, J., Gan-Or, Z., Reilly, M.M. and Coleman, M.P. (2021) “Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders”. eLife.
  • Gould S. A., Gilley, J., Ling, K., Jaffar-Nejad, P., Rigo, F., Coleman, M.P. (2021) Sarm1 Haploinsufficiency and Low Expression Levels after Antisense Oligonucleotides Delays Programmed Axon Degeneration. Cell Rep. 37: 110108.https://doi.org/10.1016/j.celrep.2021.110108
  • Hopkins, E.L., Gu, W., Kobe, B. and Coleman, M. P. (2021) A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate Immunity. Frontiers in Molecular Biosciences, 8, 703532. https://doi.org/10.3389/fmolb.2021.703532.
  • Gould, S.A., White, M., Wilbrey, A.L., Por, E., Coleman, M.P. and Adalbert, R. (2021) Protection against oxaliplatin-induced mechanical and thermal hypersensitivity inSarm1-/- mice. Exp. Neurol. 338: 113607. DOI: 10.1016/j.expneurol.2021.113607
  • Loreto, A., Angeletti, C., Gilley, J., Arthur-Farraj, P., Merlini, E., Amici, A., Desrochers. L.M., Wang, Q., Orsomando, G., Coleman, M.P. (2020). Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity. BioRxiv 2020.09.18.30426 (and under review)
  • Mabbitt, P.D., Loreto, A., Dery, M.A., Fletcher, A.J., Stanley, M., Pao, K.C., Wood, N.T., Coleman, M.P., and Virdee, S. (2020) Structural basis for RING-Cys-relay E3 ligase activity and its role in axon integrity. Nat Chem Biol 16: 1227-1236.
  • Hill, C.S., Sreedharan, J., Loreto, A., Menon, D.K. and Coleman, M.P. (2020) Loss of highwire protects against the deleterious effects of traumatic brain injury in drosophila melanogaster. Frontiers in Neurology. eCollection 2020: doi: 10.1016/j.nbd.2019.104678.
  • Dembny, P., Newman, A.G., Singh, M., Hinz, M., Szczepek, M., Krüger, C., Adalbert, R., Dzaye, O., Trimbuch, T., Wallach, T., Kleinau, G., Derkow, K., Richard, B.C., Schipke, C., Scheidereit, C., Stachelscheid, H., Golenbock, D., Peters, O., Coleman, M.P., Heppner, F.L., Scheerer, P., Tarabykin, V., Ruprecht, K., Izsvák, Z., Mayer, J., Lehnardt, S. (2020) Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors. JCI Insight. Apr 9;5(7):e131093. doi: 10.1172/jci.insight.131093. PMID: 32271161; PMCID: PMC7205273.
  • Durrant, C.S., Ruscher, K., Sheppard, O., Coleman, M.P.* and Özen, I. (2020) Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling. Cell Death Dis. 11: 98. https://www.nature.com/articles/s41419-020-2288-4
  • Coleman, M.P. and Höke, A. (2020) Programmed axon degeneration: from mouse to mechanism to medicine. Nat Rev Neurosci 21: 183–196. https://www.nature.com/articles/s41583-020-0269-3
  • Adalbert, R., Kaieda, A., Antoniou, C., Loreto, A., Yang, X., Gilley, J., Hoshino, T., Uga, K., Makhija, M., and Coleman, M.P. (2019) Novel HDAC6 inhibitors increase tubulin acetylation and rescue axonal transport of mitochondria in a model of Charcot-Marie-Tooth Type 2F. ACS Chem Neurosci. https://doi.org/10.1021/acschemneuro.9b0033
  • Loreto, A., Hill, C., Hewitt, V.L., Orsomando, G., Angeletti, C., Gilley, J., Lucci, C., Sanchez-Martinez, A., Whitworth, A.J., Conforti, L., Dajas-Bailador, F., and Coleman, M.P. (2019) Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration. Neurobiol Dis 134: 104678. https://doi.org/10.1016/j.nbd.2019.104678
  • White, M., Lin, Z., Kim, E., Hestridge, C., Altamira, E., Hunt, C., Burchill, E., Callaghan, I., Loreto, A., Brown-Write, H., Mead, R., Simmons, C., Cash, D., Coleman, M.P., and Sreedharan, J. (2019) Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss. Acta Neuropathologica Communications. 7: 166. https://doi.org/10.1186/s40478-019-0800-9
  • Horsefield, S., Burdett, H., Zhang, X., Manik, M., Shi, Y., Chen, J., Qi, T., Gilley, J., Lai, J., Rank, M., Casey, L., Gu, W., Ericsson, D., Foley, G., Hughes, R. Bosanac, T., von Itztein, M., Rathjen, J., Nanson, J., Boden, M., Dry, I., Williams, S., Staskawicz, B., Coleman, M.P., Ve, T., Dodds, P*., and Kobe, B.* (2019) Structural basis of NAD+-cleavage activity by animal and plant TIR domains with functions in cell-death pathways. Science.https://doi.org/10.1126/science.aax1911
  • Lukacs, M.*, Gilley, J.*, Zhu, Y*, Orsomando, G., Angeletti, C., Liu, J., Yang, X., Park, J., Hopkin, R.J., Coleman, M.P., Zhai, R.G., and Stottmann, R.W. (2019).  Severe biallelic loss-of-function mutations in NMNAT2 in two fetuses with fetal akinesia deformation sequence. Exp Neurol. 320. https://doi.org/10.1016/j.expneurol.2019.112961
  • Huppke, P., Wegener, E., Gilley, J., Angeletti, C., Kurth, I., Drenth, J.P.H., Stadelmann, C., Barrantes-Freer, A., Brück, W., Thiele, H., Nürnberg, P., Gärtner, J., Orsomando, G., and Coleman, M.P. (2019). Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia. Exp Neurol.320. https://doi.org/10.1016/j.expneurol.2019.112958
  • Sheppard, O., Coleman, M.P., and Durrant, C.S. (2019). Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta. Journal of Neuroinflammation.16: 106. https://doi.org/10.1186/s12974-019-1490-8
  • Hill, C.S., Menon, D.K., Coleman, M.P. (2018). P7C3-A20 neuroprotection is independent of Wallerian degeneration in primary neuronal culture. Neuroreport. 12;29(18):1544-1549. 10.1097/WNR.0000000000001146
  • Gilley, J., Mayer, P., Yu, G., and Coleman, M.P. (2018). Low levels of NMNAT2 compromise axon development and survival. Human Molecular Genetics. ddy356. https://doi.org/10.1093/hmg/ddy35
  • Adalbert, R., Milde, S., Durrant, C., Ando, K., Stygelbout, V., Yilmaz, Z., Gould, S., Brion, J.P., and Coleman, M.P. (2018). Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport. Neurobiol Aging. 68:68-75. https://doi.org/10.1016/j.neurobiolaging.2018.03.033
  • White, M.A., Kim, E., Duffy, A., Adalbert, R., Phillips, B.U., Peters, O.M., Stephenson, J., Yang, S., Massenzio, F., Lin, Z., Andrews, S., Segonds-Pichon, A., Metterville, J., Saksida, L.M., Mead, R., Ribchester, R.R., Barhomi, Y., Serre, T., Coleman. M.P., Fallon, J., Bussey, T.J., Brown Jr, R.H., and Sreedharan J.(2018). TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD. Nature Neuroscience 21: 552–563. https://doi.org/10.1038/s41593-018-0113-5
  • Fricker, M., Tolkovsky, A.M., Borutaite, V., Coleman, M.P., and Brown, G.C. (2018). Neuronal cell death.Physiological Reviews. 98(2):813-880. https://doi.org/10.1152/physrev.00011.2017
  • Carpi, F.M., Cortese, M., Orsomando, G., Polzonetti, V., Vincenzetti, S., Moreschini, B., Coleman, M.P., and Magni, G. (2018). Simultaneous quantification of nicotinamide mononucleotide and related pyridine compounds in mouse tissues by UHPLC-MS/MS. Sep Sci plus. 1(1):22-30. https://doi.org/10.1002/sscp.201700024
  • Gilley, J., Ribchester, R.R., and Coleman, M.P. (2017). Sarm1 deletion, but not WldS, confers lifelong rescue in a mouse model of severe axonopathy. Cell Reports. 21(1):10-16. https://doi.org/10.1016/j.celrep.2017.09.027
  • Di Stefano, M., Loreto A., Orsomando, G., Mori V., Zamporlini, F., Hulse, R.P., Webster, J., Donaldson, L.F., Gering, M., Raffaelli, N., Coleman, M.P., Gilley, J., and Conforti L. (2017). NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo. Current Biology. 27(6):784-794. https://doi.org/10.1016/j.cub.2017.01.070

 

  • Hung, C., and Coleman, M.P. (2016). KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons. Traffic. 17(11):1155-67. https://doi.org/10.1111/tra.12428
  • Harwell, C.S., and Coleman, M.P. (2016). Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice. Mol. Neurodeg. 11(1):44. https://doi.org/10.1186/s13024-016-0110-7

      −Ranked one of Molecular Neurodegeneration’s most influential articles in 2016.

  • Clark, D.E., Waszkowycz, B., Wong M, Lockey, P.M., Adalbert, R., Gilley, J., Clark, J., and Coleman, M.P. (2016). Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies. Bioorganic Med. Chem. Lett.26(12):2920-6. https://doi.org/10.1016/j.bmcl.2016.04.039
  • Hill, C.S., Coleman, M.P.and Menon, D.K. (2016). Traumatic axonal injury: mechanisms and translational opportunities. Trends Neurosci. 39(5):311-24. https://doi.org/10.1016/j.tins.2016.03.002
  • Gilley, J., Ando, K., Seereeram, A., Rodriguez-Martin, T., Pooler, A.M., Sturdee, L., Anderton, B.H., Brion, J.P., Hanger, D.P. and Coleman, M.P. (2016). Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice. Neurobiol Aging. 39:1-18. https://doi.org/10.1016/j.neurobiolaging.2015.11.028
  • Rodriguez-Martin, T., Pooler, A.M., Lau, D.H.W., Morotz, G.M., De Vos, K.J., Gilley, J., Coleman, M.P., and Hanger, D.P. (2016). Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons. Neurobiol. Dis. 85: 1-10.https://doi.org/10.1016/j.nbd.2015.10.007
  • Mundinger, T.O., Cooper, E., Coleman, M.P., and Taborsky Jr., G.J. (2015) Short-term diabetic hyperglycemia suppresses celiac ganglia neurotransmission, thereby impairing sympathetically mediated glucagon responses. Am. J. Physiol. 309(3): E246-255. https://doi.org/10.1152/ajpendo.00140.2015
  • Gilley, J., Orsomando, G., Nascimento-Ferreira, I., and Coleman, M.P. (2015) Absence of SARM1 rescues development and survival of NMNAT2-deficient axons. Cell Rep. 10(12): 1974-1981. https://doi.org/10.1016/j.celrep.2015.02.060

 

  • Godzik, K. and Coleman, M.P. (2015). The axon-protective WldS protein partially rescues mitochondrial respiration and glycolysis after axonal injury. J. Mol. Neurosci.55: 865-871. https://doi.org/10.1007/s12031-014-0440-2

  • Milde, S. and Coleman, M.P. (2014). Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor Nmnat2. J. Biol. Chem.289(47): 32858-32870.

    https://doi.org/10.1074/jbc.M114.582338

  • Milde, S*., Adalbert, R.*, Elaman, M.H. and Coleman, M.P. (2014) Axonal transport declines with age in two distinct phases separated by a period of relative stability. Neurobiol. Aging36: 971-981. https://doi.org/10.1016/j.neurobiolaging.2014.09.018
  • *Di Stefano, M., *Nascimento-Ferreira, I., Orsomando, G., Mori, V., Brown, R., Janeckova, L., Gilley, J., Loreto, A., Vargas, M., Worrell, L.A., Tickle, J., Herd-Smith, A., Godzik, K., Patrick, J., Webster, J.R.M., Marangoni, M., Carpi, F., Pucciarelli, S., Meng, W., Sagasti, A., Ribchester, R.R., Magni, G. and *Coleman, M.P., and *Conforti, L. (2014). A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration. Cell Death Diff.22: 731-742. https://doi.org/10.1038/cdd.2014.164
  • *Conforti, L., *Gilley, J., and Coleman, M.P. (2014). Wallerian degeneration: an emerging axon death pathway linking injury and disease. Nat. Rev. Neurosci.15: 394-409. https://doi.org/10.1038/nrn3680
  • Marangoni, M., Adalbert, R., Janeckova, L., Patrick, J., Kohli, J., Coleman, M.P. and Conforti, L. (2014) Age-related axonal swellings precede other neuropathological hallmarks in a knock-in mouse model of Huntington's disease. Neurobiol Aging35(10): 2382-2393. https://doi.org/10.1016/j.neurobiolaging.2014.04.024

Selected older publications

  • Milde, S., Fox, N.A., Freeman, M.R. and Coleman, M.P. (2013) Deletion of exon 6 and nearby sequences transforms the protective capacity of axon survival factor Nmnat2 in vivo. Nature Scientific Reports. 3: 2567
  • Gilley, J., Adalbert, R., Yu, G., and Coleman, M.P. (2013) Rescue of PNS and CNS axon growth and survival defects in mice lacking NMNAT2. J Neurosci.33: 13420-24
  • Milde, S., Gilley, J., and Coleman, M.P. (2013) Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2. PLoS Biol 11(4): e1001539
  • Adalbert, R., and Coleman, M.P. (2012) Axon pathology in age-related neurodegenerative disorders.Neuropath Appl Neurobiol39: 90-108
  • Osterloh, J.M., Yang, J., Rooney, T.M., Fox, A.N., Adalbert, R., Powell, E.H., Sheehan, A.E., Avery, M.A., Hackett, R., Logan, M.A., MacDonald, J.M., Ziegenfuss, J.S., Milde, S., Hou, Y-J., Nathan, C., Ding, A., Brown, R.H. Jr., Conforti, L., Coleman, M.P., Züchner, S., Tessier-Lavigne, M. and Freeman, M.R. (2012). dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science337: 481-4
  • Gilley, J., Seereeram, A. Ando, K., Mosely, S., Andrews, S., Kerschensteiner, M., Misgeld, T., Brion, J-P., Anderton, B., Hanger, D.P. and Coleman, M.P.(2011) Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a ‘P301L’ tau knock-in mouse. Neurobiol Aging 33: 621e1-15
  • Andrews, S., Gilley, J., and Coleman, M.P. (2010) Difference Tracker: ImageJ plugins for fully-automated analysis of multiple axonal transport parameters J Neurosci. Meth193: 281-7
  • Babetto, E., Beirowski, B., Janeckova, L., Brown, R., Thomson, D., Ribchester, R.R., and Coleman, M.P.(2010) Targeting Nmnat1 to axons and synapses transforms its neuroprotective potency in vivo. J Neurosci. 30: 13291-13304
  • Coleman, M.P. and Freeman, M.R. (2010) Wallerian degeneration, WldS and Nmnat. Ann Rev Neurosci.33: 245-67
  • Gilley, J., and Coleman, M.P. (2010) Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons. PLOS Biol 8: (1) e1000300 doi: 10.1371/journal.pbio.10000300
  • Conforti, L., Wilbrey, A., Morreale, G., Janeckova, L., Beirowski, B., Adalbert, R., Mazzola, F., Michele Di Stefano, Hartley, R., Babetto, E., Smith, T., Gilley, J., Billington, R.A., Genazzani, A.A., Ribchester, R.R., Magni, G., and Coleman, M.P.(2009) WldS protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice.J Cell Biol 184: 491-500
  • Beirowski, B., Babetto, E., Gilley, J., Mazzola, F., Conforti, L., Janeckova, L., Magni, G., Ribchester, R.R., and Coleman, M.P. (2009) Non-nuclear WldS determines its neuroprotective efficacy for axons and synapses in vivo.J Neurosci 29: 653-68
  • Adalbert, R., Nogradi,A., Babetto, E., Janeckova, L., Walker, S.A., Kerschensteiner, M., Misgeld, T. and Coleman, M.P.(2009) Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies. Brain 132: 402-16
  • Beirowski, B., Babetto, E., Coleman, M.P. and Martin, K.R. (2008)The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model. Eur J Neurosci.28: 1166-79
  • Conforti, L., Fang, G., Beirowski, B., Wang, M.S., Sorci, L., Asress, S., Adalbert, R., Silva, A., Bridge, K., Magni, G., Glass, J.D., Coleman, M.P. (2007) NAD+ and axon degeneration revisited: Nmnat1 cannot substitute for WldS to delay Wallerian degeneration.Cell Death and Differentiation 14: 116-27
  • Coleman, M.P. (2005) Axon degeneration mechanisms: commonality amid diversity Nature Reviews Neuroscience6: 889-898
  • Beirowski, B., Adalbert, R., Wagner, D., Grumme, D.S., Addicks, K., Ribchester, R.R. and Coleman, M.P. (2005) The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves.BMC Neuroscience6: 6
  • Adalbert, R., Gillingwater, T.H., Haley, J.E., Bridge, K., Beirowski, B., Berek, L., Wagner, D., Grumme, D., Thomson, D., Addicks, K., Ribchester, R.R. and Coleman, M.P. (2005) A rat model of slow Wallerian degeneration (WldS) with improved preservation of synapses.Eur. J. Neurosci.21: 271-277
  • Mi, W., Beirowski, B., Gillingwater, T.H., Adalbert, R.J., Wagner, D., Grumme, D., Conforti, L., Arnhold, S., Addicks, K., Wada, K., Ribchester, R.R. and Coleman, M.P. (2005). The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice Brain 128: 405-416
  • Beirowski, B., Berek, L., Adalbert, R., Wagner, D., Grumme D.S., Addicks, K., Ribchester, R.R. and Coleman, M.P. (2004) Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labeling in YFP-H mice.J. Neurosci. Meth.134: 23-35
  • Samsam, M., Mi, W., Wessig, C., Zielsek, J., Toyka, K.V., Coleman, M.P., and Martini, R. (2003).The WldS mutation delays robust loss of motor and sensory axons in a genetic model of myelin-related axonopathy.J. Neurosci.23: 2833-9
  • Ferri, A., Sanes, J., Coleman, M.P., Cunningham, J.M., and Kato, A.C. (2003) Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease.Curr. Biol.13: 669-73
  • Coleman, M.P. and Perry, V.H. (2002) Axon pathology in neurological disease: a neglected therapeutic target.Trends Neurosci.25: 532-7
  • Mi, W., Conforti, L. and Coleman, M.P. (2002) A genotyping method to detect a unique neuroprotective factor for axons (WldS)J. Neurosci. Meth.113: 215-218
  • Mack, T.G.A., Reiner, M., Beirowski, B., Mi, W., Emanuelli, M., Wagner, D., Thomson, D., Gillingwater, T., Court, F., Conforti, L., Fernando, F.S., Tarlton, A., Andressen, C., Addicks, K., Magni, G., Ribchester, R.R., Perry, V.H., and Coleman, M.P. (2001) Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene Nature Neuroscience4: 1199-1206
  • Conforti, L., Tarlton, A., Mack, T.G.A., Mi, W., Buckmaster, E.A., Wagner, D., Perry, V.H., and Coleman, M.P. (2000) A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the Slow Wallerian Degeneration (WldS) mouse.Proc. Natl. Acad. Sci.97: 11377-11382
  • Coleman, M.P., Conforti, L., Buckmaster, E.A., Tarlton, A., Ewing, R.M., Brown, M.C., Lyon, M.F., and Perry, V.H. (1998) An 85kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse. Proc. Natl. Acad. Sci.95: 9985-9990